IInd Dept. of Anat.(Head: Prof. K. FUJIE) and Dept. of Surgery, IInd Clinic (Head: Prof. Y. NAKAO), Wakayama Med. College, Wakayama. Experimental Study on the Secretory Activity of the Gastric Chief Cells in the Operated Stomach

peutics in the case of the gastric and duodenal ulcer. In recent times, the advance and the improvement of operation method, narcosis, transfusion and antibiotics etc. combine to give greater success in this type of operation. However, though recidivation of the ulcer is arrested, it cannot be said that there are no undesirable effects for the individual in an operation which entails resection of the greater part of the stomach. This is because the stomach itself plays such an important role in the digesting and preservation of food, in secreting gastric juice, in making chymus etc. Therefore the technique of operating, which, while arresting recidivation of the ulcer preserves the stomach as much as possible together with its digestive activity is greatly to be desired. The first to introduce vagotomy in the therapy of the peptic ulcer, for this pur pose, were DRAGSTEDT and OWENS (1943). This method, however, has not been adopted because of the fact that the vagotomy alone brings about a gastric stasis, a lesser inhibition of acid secretion and a lesser degree of ulcer recidivity. As a result of progressive investigation on the gastric secretion and the etiology of the ulcer, the operation combining the gastric resection and the vagotomy was employed in a new attempt. SMITHWICK used hemigastrectomy with vagotomy and EDWARDS ant rectomy with vagotomy, BEATTIE tested pylorectomy with vagotomy, SMITH and FARRIS employed pyloroplasty with vagotomy. These operations have attracted notice as a conservative gastrectomy and, at present, hemigastrectomy with vagotomy is widely used. These aim at a lesser secretion of acid and the preservation of the greater